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Bioinformatician

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Deutsches Krebsforschungszentrum DKFZ
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- Teljes munkaidő
- Általános munkarend
Elvárások
- Angol középfok
- 1-3 év tapasztalat
- Egyetem

Teljes munkaidő Általános munkarend

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Responsibilities

The Department of Translational Medical Oncology investigates the molecular and cellular mechanisms for cancer development, proliferation, and evolution. To strengthen our expertise in bioinformatics and machine learning, we are offering a position for a highly motivated scientist with significant experience in bioinformatics, ideally in the field of cancer research. You will be given the opportunity to develop your own research profile and standing in precision oncology and are expected to support the department's research projects as well as write your own grant applications. The position is integrated in a multidisciplinary team of clinicians, scientists, and bioinformaticians and offers access to the MASTER dataset. As a successful applicant, you will drive your own research, analyze NGS and other high-throughput data from patient cohorts and work on the development of improved NGS data analysis algorithms and design novel applications, e.g., for the integration of different data types.

Requirements

Significant expertise in bioinformatics or/and life sciences, with an excellent background in NGS analysis and relevant experience in the field, ideally with a PhD
Background knowledge in cancer genomics
Proficiency in Bash scripting and R and experience with cloud computing (required)
Proficiency in Python and Git (preferred)
Ability to perform bioinformatic and statistical analyses of multi-tier molecular profiling data, including NGS and single-cell NGS, and drive the development and implementation of new technologies
High level of self-motivation and the ability to develop and pursue research projects independently as well as in collaboration
Excellent written and spoken English skills and strong communication skills

Applications should include a CV, cover letter, certificates, expected availability date, a complete list of publications and 2–3 references.

What we offer

Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level
30 days of vacation per year
Flexible working hours
Remuneration according to TV-L incl. company pension scheme and capital-forming benefits
Possibility of mobile work and part-time work
Family-friendly working environment
Sustainable travel to work: subsidized Germany job ticket
Unleash your full potential: targeted offers for your personal development promote your talents
Our Corporate Health Management Program offers a holistic approach to your well-being

Company info

The German Cancer Research Center (DKFZ) is one of Europe's largest cancer research centers. “Research for a life without cancer" is the mission of our world-class scientists and all our team members.

The DKFZ is a place where the brightest minds pursue bold ideas and seek answers to pioneering scientific questions through collaboration, innovation, and exploration across many disciplines. We provide a dynamic environment which empowers excellence with state-of-the-art technologies, cutting edge infrastructure, and a global scientific network.

Contribute your knowledge, vision, and dedication to create a space where scientific discovery in cancer research is transformed into benefits for human health.

The National Center for Tumor Diseases (NCT) is a long-term cooperation between the German Cancer Research Center, excellent partners in university medicine and other research institutions at six locations in Germany. The goal of the NCT is to bring promising results from cancer research into clinical application quickly and safely. This approach is intended to provide cancer patients with nationwide access to innovative treatment options.

One of the six NCT sites is the NCT Dresden (NCT/UCC), which is a collaboration between the DKFZ, the University Hospital Carl Gustav Carus Dresden (UCC), the Carl Gustav Carus Medical Faculty of the TU Dresden and the Helmholtz Center Dresden-Rossendorf (HZDR).

For the Department of Translational Medical Oncology at the NCT site Dresden, we are seeking for the next possible date a Bioinformatician.

Reference number: 2025-0297

Dresden
Full-time
NCT Dresden - Translational Medical Oncology

NCT and DKFZ have laid the groundwork to address new challenges in personalized oncology through the MASTER program. This prospective registry trial employs very comprehensive molecular profiling and integrated data analysis (WGS/WES, RNA sequencing, genome-wide DNA methylation profiling; whenever possible, mass spectrometry-based (phosphor)proteomics, ex vivo drug sensitivity profiling, and spatial resolution of the immune environment). Based on the MASTER workflow, we provide clinically relevant management recommendations in a multicenter molecular tumor board (MTB) and follow up on clinical management of patients. The resulting multidimensional clinical and molecular dataset has kick-started very successful interdisciplinary research projects (e.g., Heining et al. Cancer Discov 2018, Gröschel et al. Nat Commun 2019, Horak et al. Cancer Discov 2021, Möhrmann et al. Nat Commun 2022, Jahn et al. Ann Oncol 2022).